Blue Scorpion venom and its use in the treatment of Cancer

It is said that the color blue depicts appearance, shyness, easiness and sex appeal but would you believe that the same blue color has remedial properties. Yeah! The blue scorpions possess such qualities. Rhopalurus junceus, or blue scorpion venom, patented from Cuba, is every so often promoted as having anti-malignant anti-inflammatory, and analgesic features. A homeopathic variety, Vidatox, has since been established.

Scorpions are voracious arthropod animals of the order Scorpiones within the class Arachnida.

These arthropods own a poisonous stinger at the termination of their tails which not only causes a burning or stinging sensation but serves to paralyze its victim.

The conviction that scorpions have therapeutic possessions has been present for many eras, and many examples of their use have been documented in both native and traditional medicine.

Venoms of Scorpions

 Scorpion toxins are proteins found in the venom of scorpions and their task at the molecular level is to impede ion channels.  It prefers fastening to sodium channels, impeding the non-incitement of galvanized channels and hindering neuronal communication.

Uses of scorpion venoms:

 Venoms hold gorgeous supplies of numerous bioactive compounds that own beneficial abilities. Scorpion venoms comprise several peptides of small molecular weight. These have extensive pharmacological actions including anti-malignant activities.

Blue scorpion venom and its use for treatment of cancer

Rhopalurus junceus (the toxin of blue scorpion) is frequently marketed as having anti-malignant features. The proclaims for the serum of blue scorpion—– Escozine and Escozul, originate from experiments implicating Chlorotoxin—- a 36 amino acid peptide originated from scorpion venom which serves to obstruct small-conductance chloride passages.

The very fact that Chlorotoxin has a tendency to attach to glioma cells {a kind of tumor that arises in the brain and spinal cord; glioma} has permitted the development of new techniques for the management and identification of numerous types of malignancies.

Dr. Mikaelian, Watts and Escozine

Russian expatriate Dr. Arthur Mikaelian and his corporation Medolife, created a prescription known as Escozine; and the only dynamic component of Escozine is the poison of the blue scorpion. Dr. A. Mikaelian and his companion Sebastian Serrel Watts accredit marvelous capabilities to Escozine. Besides hitting malignant cells, scorpion poison may also combat auto-immune ailments, HIV, hepatitis, and all the more so male impotence.

When enquired why huge pharmacological corporations {which expend billions of bucks on research of malignancy every year} haven’t promoted scorpion toxin, Dr. Mikaelian alleged that pharmacological corporations don’t review biological compounds for the reason that you can’t copyright biological merchandise.

Medolife propagates a huge cluster of scorpions at a scorpion sanctuary in the Dominican Republic. The poison of Scorpion is hauled out in a self-effacing chartered lab in Santo Domingo. There every scorpion generates merely five to seven drops of toxin each month, and merely a miniature quantity is implanted into tiny bottles, which are sold for 700 dollars each—- a thirty day amount for the typical purchaser.

Even though he said he is sure his drug can combat malignancy, Mikaelian accepted that the drug needs extensively more exploration.

On its website, Medolife purported that Escozine is a biological medicine sanctioned and proficient for oncological usages. As stated by Watts, the same medicine is also catalogued in Russia, Belarus, Kasazkstan and Vietnam. During the  eight-year medical investigation of Medolife {which registered 8,302  patients suffering from malignancy with diverging sorts of  gravity} Escozine was established to have an almost ninety  percent success rate in amending value of life, which involved everything from reduced pain to better degrees of survival.

Tumor paint–a step forward in research on malignancy

 The FDA gave its approval to give a shot of the malignancy-identifying compound referred to as tumor paint {prepared from the venom of death stalker scorpions} to 21 patients (suffering from malignancy of brain.) This compoundsanctions surgeons to locate malignant tissue during surgery since it becomes luminous under laser light.
It was procreated after a girl aged seventeen years went through a surgery for a period of seventeen hours; the surgery was undertaken to take out a malevolent tumor in her brain. Notwithstanding all the challenging work, surgeons were powerless to eliminate all the carcinomatous tissue since some was concealed behind flawlessly normal brain tissue. The pediatric oncologist—Dr. Olson and his squad found that a Chlorotoxin present in the poison of the deathstalker scorpion could fasten itself to malignant cells in rats and when it does so, it tumbles inside the malignant cells and causes them to irradiate so the surgeon is able to perceive them in real time while he/she is operating. The tumor paint is now being tested on human beings and if the human statistics turn out to be worthy, it will go a long way to reform malignancy surgery.

Findings of another research study

A research investigation carried out at the University of Colima {South-West state of Mexico} has recognized a carefully chosen group of peptides {in the poison of the scorpion Centruroides tecomanus} to possess anti-malignant properties. When the poison attacks passages in the malignant cells, it creates cellular injury and murders the cells.

The narrative of Peggy Howe

 The Kansas grandma Peggy Howe was identified with stage-four breast malignancy in the year 2011. In the face of substantial chemotherapy and radiation, Howe’s malignancy extended to her liver and lungs. As a final attempt to save her life, Howe started taking Escozine. Within a period of ninety-six hours, she started experiencing more energy and subsequently during a period of six months, the malignancy vanished. Howe was so happy that she even acquired a scorpion tattoo on her ankle. However, as stated by her, the malignancy relapsed after she discontinued the intake of Escozine. With full conviction she plans to use the same drug once again.

The programmed cell death {apoptosis} in breast cancer cell lines

Exploratory estimates specify that the poisons of Tityus discrepans, Androctonus crassicauda, and Odontobuthus doriae serve as activators of programmed cell death in breast cancer cell lines.Two unique peptides termed neopladine 1 and neopladine 2 have been filtered from Tityus discrepans scorpion toxin and found to be dynamic on human breast carcinoma SKBR3 cells. {SkBr3 is a cell line quarantined by the Memorial Sloan–Kettering Cancer Center in 1970. It was developed from a pleural effusion secondary to an adenocarcinoma discovered in the breast of a white-skinned woman who was forty- three years of age.}

BmKAEP (anti-epilepsy peptide) is a neurotoxin from the poison of the Manchurian scorpion (Mesobuthus martensii). It is a β-toxin, which modifies the galvanization voltage of sodium passages towards more negative potentials.

 The same neurotoxin impedes the propagation of human leukemia cells signifying beneficial prospective in malignancies associated with formation of blood cells.

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