The battle against cancers is slowly inching towards victory with our group of researchers at the forefront battling them. Researchers from all over the world have joined forces to tackle cancers. Some focus on its behavior, how to early detect these cells – before they turn into a mass of cells rampaging our body, and eventually killing it – and prevent it from occurring, while others focus on battling it upfront when these cells have grown enough in numbers to conquer or ‘metastasize’ to all parts of the human body.
Cancer is difficult to defeat once it ambushes our body with its troops of ‘zombie’ cells. These cells are literally eternal as long as the host body lives on. Cancer cells accumulated six hallmarks of cancer mutations to render them the ability to divide continuously, uncontrollably and rapidly. They do not conform to the natural law of cellular aging and apoptosis. These cells continue to grow, compete and deprive the normal cells of their nutrients. The latter lose their physiologic function, and the affected body is then slowly taken down from the inside. Getting rid of these cells is no easy feat since they exist among normal cells. Any cytotoxic drugs targeted to kill cancer cells will then inevitably affect the normal cells too – the chemotherapy and radiotherapy side effects. Researches from around the world are united in developing ‘weaponries’ with less to negligible side effects, to fight cancer cells. The common modalities used are surgery, chemotherapy and radiotherapy, but developing a targeted therapy with low or negligible side effects remains a daunting task.
A group of researchers in the 1980s was interested in the geographic pattern of cancer occurrence. They found out that in certain regions of the world, cancer occurrence is low. The finding prompted scientific questions of possible environmental correlation. Studies were done, and they found out that in those regions consistent data supported the positive correlation of high concentration of alkali metals in the soil. In 1920s, some researchers suggested that cesium might be an effective anti – cancer agent, but a decade later, further studies suggested minimal effect of cesium chloride on tumor growth. It was until the 1984, a comprehensive study on rats and human by Dr. Brewer revealed that Cesium chloride did reduce tumor size, alleviate cancer related pain, and kill cancer cells with negligible side effect on normal cells. The popularity of Cesium chloride as anti cancer agent once again resurfaced.
The mechanism of action behind the efficacy of Cesium chloride is currently not fully understood. Dr. Brewer in his study did suggest a ‘high pH’ mechanism. Cesium is a cation which is readily absorbed by cancer cells, but not by normal cells. The intake of Cesium by cancer cells change its pH environment from acidic to basic, which is unfavorably for the cancer cells. Cancer cells activity will then halt, and at higher pH level, the cancer cells will eventually damaged and killed.
Normal cells under normal metabolic activity, receives ample supply of oxygen and nutrients from the blood. The cells take on glucose catabolism under aerobic condition, to generate ATP or cellular energy unit, to power the cell to carry out its physiologic task. In demanding condition, such as heavy exercise, cellular metabolic demand increase while blood supply may not be fast enough to meet the oxygen need. The cells switch to anaerobic metabolism, still producing ATPs but in a less efficient way. The by – product of this activity is the accumulation of lactic acid, creating a low pH environment, known as acidosis. Human body has a buffer system to momentarily counterbalance the resulting acidosis. The accumulated lactic acid must then be converted back again to glucose in high oxygen environment in order for it to be utilized by the cells. This activity, also known as the Cori cycle, is done with an expense of 6 ATPs per lactate molecule. The switch to lactic acid metabolism may not be efficient in terms of energy expenditure, but it maintains the energy supply to the cells – despite the relatively small amount of ATP – in low oxygen situation. When internal body environment is back to high oxygen condition, the system has to pay the energy debt of using this ‘lactic acid’ facility; 6 ATPs per lactic acid molecule.
Cancer cells operate efficiently in the same condition explained previously. These cells multiply rapidly. In order to meet the cellular building blocks requirement, cancer cells induce growth of blood vessels to supply themselves, an action known as angiogenesis. However, despite the angiogenesis attempt, the cells multiply even more rapidly, that often the case these new blood supplies are unable to catch up. It is not uncommon to find rapidly growing tumors with central necrosis or cell death, since the centre cells do not receive enough nutrients to remain alive. Cancer cells are therefore highly adapted to anaerobic metabolism which generates high hydrogen ions concentration, creating an acidic environment.
Cancer cells derive their ATP mostly from anaerobic or the lactic acid pathway due to their high rate of multiplication. It is an inefficient way of producing ATP. The lactic acid will be fed to the liver trough the Cori cycle to be reconverted to glucose to feed the cancer cells again. For each glucose molecule, 2 ATPs are generated by lactic acid pathway to feed the cancer cells, at a cost of 6 ATPs. There is a net loss of 4 ATPs per glucose molecule. This ‘miracle circle’ explains the wasting or cachexic syndrome observed in most cancer patient. Cation, mainly Cesium helps to break this circle by creating an alkali environment, balancing the excess of hydrogen ions to reduce formation of lactic acid.
Cancer cells lives in acidic environment, and deals well with it, while normal cells do not. As cancer cells grow, lactic acid production increases which is unfavorable to normal cells. The intake of Cesium chloride is easier by cancer cells than by normal cells. The high concentration of this cation in the cancer cells changes the pH environment from low pH or acidic, to high pH or alkali environment. It is suggested then that cancer cells do not operate well in alkali environment, thus cease their activity, and most likely at higher level resulting in the death of cancer cells.
Early studies at American University in Washington were done in rats with implanted cancer cells in the abdomen. The cells were allowed to grow for 8 days after which the rats were divided into two groups, one serving as controls while the other group was treated with alkali metal. The control group died 13 days afterwards, while the treated group remained alive with subtle sign of cancers. All remaining rats were sacrificed, and post mortem autopsy revealed that the tumor size of the treated rats were on average only one eleventh of the control group. Similar research was done at Platteville, carrying it further by directly injecting Cesium chloride intraperitoneally. It was reported 97% curative effect in the treated group, with drastic shrinkage in tumor mass.
Tests in human were first carried out by H. Nieper in Hannover, Germany and by H. Sartori in Washington D.C. The results were reported to be satisfactory. The studies designed to administer 2 gram of Cesium chloride three times daily with meal together with high dose Vitamin C, A, and Zinc. The treated patients reported prompt relieve of cancer related pain. Better news was that the tumors also shrink significantly. Indirect measurement was also done by measuring the uric acid content in the urine. Cellular death or turnover can be traced indirectly by uric acid level since the death of cells will translate to more exposed nuclear components which are metabolized by the body into its constituents, including uric acid. The treated patients revealed increase in uric acid level post Cesium therapy which suggested that cancer cells death was increased.
High pH environment is not favorable by normal cells. Human cells operate in an almost constant internal environment, a condition known as homeostasis. The optimum pH range is 7.35 -7.45. The body system will work autonomically to maintain that balanced internal environment. The problem with most high pH treatment is that it exposes the whole body to alkali environment which is not beneficial for physiologic activity. Cesium chloride supplementation, however, provides a targeted high pH effect on cancer cells due to these cells readily absorb the cation more than normal cells, hence making sure that normal cells still function at optimum pH while penalizing cancer cells with high pH environment.
Cesium chloride supplementation is safe and non – toxic as long as it is taken as recommended. Some sources reported lethal events associated with supplementation of high amount of Cesium chloride beyond recommended level.
Theoretically, high cation content in the blood may disrupt electrolyte balance in the body. The effect of this homeostatic disruption is apparent in the nerve conduction, muscle cells, and most importantly the heart. Since Cesium is a cation, administration of high amount of this compound will tilt the balance of cations in the body. Human body system will react to maintain homeostasis by pushing naturally occurring cations such as potassium intracellularly, driving blood potassium level low, a condition known as Hypokalemia. As long as intake is within recommended level with routine electrolytes screening, side effects seldom occur.
Written by Dr. Benz Napoli