CoQ10 and treatment for cancerous diseases


For more than a decade Life Extension® has published clinical studies that show the effects on people with certain cancerous diseases who used coenzyme Q10. In clinical studies not only improvementswere documented with patients but also the mechanisms by which tumor growth slows CoQ10 had also been identified. These mechanisms have included an increase in the immune system, suppression of vascular endothelial growth factor and reduction of the inflammatory markers that facilitate the spread of cancer cells. Melanoma and breast cancer are two types of malignancy in which CoQ10 showed significant clinical improvement.

Regrettably, many media didn’t advertise those important discoveries that could save many lives. One of those discoveries is the study of melanoma with or without a CoQ10 daily dose in an amount of 400mg. The results were astounding, the group that took CoQ10 had a 10-fold lower risk of metastases than those who did not take. This effect is even more expressed for those with melanoma at an advanced stage, in this case, the patients were 13 times less likely to develop metastases. After that, the National Cancer Institute which didn’t  funded further research, was very criticised, although studies have shown that this enzyme may help in the treatment of cancer. In this study, 18% of all the patients showed unwanted effects in comparison to 82% who didn’t have them. This was the reason not to continue the research by the Institute.

It was very sad to read a report by the National Cancer Institute, which presented their views on the role that CoQ10 may play in the treatment of cancer and unwanted influence of this enzyme to patients. The federal agency has given its comment: “We do not agree with the report of the National Cancer Institute in terms of the side effects related to research COQ10 which are not only a result of the enzyme but the use of toxic chemo drugs and the action of cancer. From ten thousand healthy members of the Life Extension® using COQ10 none of the patients had any side effects.

Questions and answers about coenzyme Q10

What is coenzyme Q10?

Coenzyme Q10 is a compound that is naturally produced in the organism. Q or 10 in coenzyme Q10 refer to chemical groups that form coenzyme. Coenzyme Q10 is also known by other names:

– CoQ10.

– Q10.

– Vitamin Q10.

– Ubiquinone.

– Ubidecarenone.

Coenzyme helps enzymes to do their tasks. The enzyme is a protein which boost the speed at which the natural chemical reactions are taking place in cells. The cells of the body use COQ10 to increase the energy that’s needed for growth and to remain healthy cell itself. The body also uses coenzyme Q10 as an antioxidant. The anti-oxidant is a substance that protects the cells from chemicals which are called free radicals. Free radicals can damage DNA. Damaged DNA can also be linked to some types of cancer. Coenzyme Q10 is mainly found in the larger body tissues. The largest concentration is in the heart, liver, kidneys and pancreas. The lowest concentration is in the lungs. The amount of coenzyme Q10 decreases as we age.

History of coenzyme Q10 as an ingredient in alternative cancer treatments:

Coenzyme Q10 was first identified in 1957. while its chemical structure was established in 1958. The interest in coenzyme Q10 as a possible treatment for cancer was initiated in 1961, when it was determined that some cancer patients have significantly lower levels of coenzyme. The lower level of coenzyme Q10 has been found in patients with myeloma, lymphoma, and breast, lung, prostate, pancreatic, colon, kidney, head and neck. Studies suggest that coenzyme Q10 can help improve the immune system. Partly for this reason, the coenzyme is used in adjuvant therapy for cancer.

What is the theory behind the claim that the coenzyme Q10 is useful for treating the cancer?

Coenzyme Q10 can be very useful in treating cancer because it strengthens the immune system. Studies also suggest that CoQ10 directly inhibits the growth of cancer cells. As an antioxidant, coenzyme Q10 can prevent cancer in the development.

How to use CoQ10?

The usual method is orally as a capsule. It can also be administered as an injection. In animal studies, coenzyme Q10 is used with the injection.

Animal study

Clinical studies have been done on animals with coenzyme Q10. Research has been conducted in the laboratory using animals to find out whether it will be useful with humans. These pre-clinical studies had been carried out before the human testing started. Most laboratory studies of coenzyme Q10 are based on the reactions in the body of animals. The following pre-clinical study was the ratio of coenzyme Q10 and cancer. Exploration of coenzyme Q10 in animals showed that it helps in the immune system’s boosting and helps the body in fighting certain infections. This coenzyme helped in the protection of animals hearts which were given the anticancer drug doxorubicin which could lead to the heart muscle damage. Laboratory tests on animals have shown that coenzyme Q10 inhibits the growth and development of cancer cells.

Were clinical studies carried out on humans?

Up to now, there were no well-designed clinical trials involving large numbers of people who would be studied in order to detect how coenzyme Q10 is operating during cancer treatment. There were some clinical trials with a small number of people. Almost all studies were randomized. Random studies provide the highest level of evidence. In these studies, volunteers were randomly assigned; one in two or more groups that compare different factors related to treatment in controlled studies, while another group that’s called the control group doesn’t get the new treatment. The control group is compared with groups which receive new treatments and when comparing they are able to compare the results and draw conclusions. Most scientific journals have experts who review research reports before publishing them, to affirm the evidence and draw conclusions. Some randomized trials of coenzyme Q10 as a treatment for cancer have been published in the scientific magazines. The following information were published from these studies of coenzyme Q10 on the basis of studies on humans.

Testing COQ10’s positive impact on doxorubicin

In a sample of 20 patients was performed an exploration whether the enzyme CoQ10 protects the heart from damage caused atrakcilinom from drug doxorubicin. Results of this study show that coenzyme Q10 reduces the harmful effects of doxorubicin on the heart.

Studies of coenzyme Q10 in the adjuvant therapy for breast cancer       

Small studies were done during using coenzyme Q10 after standard treatment in patients with breast cancer. It was carried out a study of coenzyme Q10 as adjunctive therapy with 32 women suffering from breast cancer. It was reported that in 6 patients disappeared symptoms of this disease. The exact details were specified in only 3 out of the 6 patients. The researchers also gave an indication that all patients improved quality of life, they used less pain medication and they did not reduce body weight. In another study two patients, who had breast cancer and who underwent surgery, were given a heavy dose of CoQ10 enzyme for 4 months. Their cancer was completely gone.

Are there any side effects with coenzyme Q10?

There weren’t any serious side effects when using CoQ10. The most common side effects are:

-Rash

-Nausea

-Insomnia

-Pain in the upper abdomen

-Dizziness

-The feeling of fatigue

-Headache

Certain drugs which are used for lowering cholesterol, blood pressureand sugar levels in blood can reduce the effectiveness of COQ10. Coenzyme Q10 can change the way the body uses warfarin and insulin.

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