Myrmecodia pendens (Sarang Semut) anti-cancer activity

The diagnosis of Doctor Samuel said that Mona Pangkey has tumor due to abnormalities of the nodes. The news was painful for the mother of one child. She redeemed the prescription of her doctor immediately at the pharmacy as she was desperate for cure. Unfortunately, the dream of complete cure is fleeting. A year after taking medicines prescribed by her doctor, the deadly disease is still not giving up on her. That is reason enough for Mona to glance at alternative herbal medicine.

However, the alternative was not doing any good either. The pain did not subside. “I was very worried and nervous because I was married and had a child”, she said. Restlessness culminated when the tumor grew and some ruptured. Pus and blood flowed from the wound. She was in pain during the three weeks of rest.

Still, hope for a cure never ended. When her husband took home a powdered Myrmecodia Sarang semut recommended by his peers, the hope again was found. It was written in the packaging; Myrmecodia Sarang semut among others is able to cure tumor and cancer. That day, in mid-2005, she started drinking the herbal decoction.

“Sarang Semut” literally means “ant hill” in Indonesia. Despite its name, Myrmecodia was not nest made by ants hung on tree top. Myrmecodia ant hill was a name of a group of epiphytic plants attached to trees. The plant group consists of 2 genuses: Myrmecodia and Hydnophytum with dozens of species. The bulbs of both plant species, Rubiaceae family members, were bulging and lined with sharp thorns. The interior of the bulb are labyrinths populated by ants and fungi. The ants, fungi and the plant are involved in mutualistic symbiosis, where ants, fungi food and body remain provides nutrition for the plant, and the plant provides secure nest in return.

Ecologically, the ant hill plant spread across mangroves and trees along the coastline to an altitude of 2400 m. Myrmecodia ant hills are most commonly found in pastures and are rarely found in lowland tropical forests, but is more commonly found in forests and agricultural areas with an altitude of about 600 m. It is often found sticking on some trees, mostly in cajuput trees, pine, kaha, and beech trees, but rarely on trees with a smooth and frail trunk such as Eucalyptus. In the wild Myrmecodia Sarang semut is inhabited by diverse species of ants and often by three species of the genus Iridomyrmex. Identification on Myrmecodia pendens shows that this plant is inhabited by a colony of ants of the species Ochetellus sp.

This plant has long been utilized by the primitive tribes in East Indonesia, as natural cure for various diseases. The bulbs are usually thinly sliced, dried, and decocted. This same potion is presented to Mona Pangkey by her husband. Every day she drank a glass of Myrmecodia anthill decoction 3 times. A month later, a lump in the neck disappear altogether along with the drying of the wound and the pain.

Mona was curious about the incident. In September 2005, she went to the doctor who first suggested having operation done on the tumor. “Doctors were amazed I have recovered,” she recalled. “Then the doctor asked if I was taking any other medications? Because he had been attending to patients with the same disease, and never seen such rapid cure as I did,” she said.

Brain tumor, Linda Hendriyani (20 years old) – Linda Hendriyani was diagnosed with brain tumor at the age of 17. For years she had been in excruciating pain. She had gone through session after session of chemotherapy, with little to no avail. Almost losing her hope, she tried ant hill plant extract recommended by her family’s apprentice. After 3 weeks of therapy, she began to observe significant improvement. The pain which is due to expanding tumor lesions subside. She can now resume normal activity.

Lung tumor, Hamir Hamid – “From the result of thoracic X- Ray and CT-Scan, specialized doctor diagnosed me with lung tumors at Fatmawati Hospital. My son in law recommended ant hill plant as an alternative treatment. After a few months, I underwent another thoracic X- Ray and CT-scan, and my doctors puzzled and hardly believe what they saw. The tumors have disappeared.”

Myrmecodia sp. (Sarang semut) / anthill plant, its acclaimed anti – cancer activity, safety, toxicity and dosage.

Mona Pangkey other patients’ (the list is exhaustive) healing is not just a coincidence. Researchers from neighboring countries prove the many patients’ claims through a series of scientific research. In vitro tests, Myrmecodia anthill was proven effective against cancer cells. To name a few of those researchers are: Qui Kim Tran from the National University of Ho Chi Minh City, and colleagues such as Yasuhiro Tezuka, Yuko Harimaya, and Arjun Hari Banskota. These Qui colleagues worked at Toyama Medical and Pharmaceutical University.

Plant weighing 2-3 kg were then extracted with various solvents such as water, methanol and methanol-water mixture. They then grew 3 types of highly metastatic cancer cells (easily spread to other parts of the body) such as cervical cancer, lung cancer, and colon cancer.

Each of these extraction results were then given to each cancer cell. The result is amazing; the Myrmecodia Sarang Semut shows antiproliferative activity. In medicine, proliferation means of cell growth is rapid and abnormal. Cancer does mean rapid uncontrolled cell growth. “Antiproliferation means inhibition of the cell proliferation process,” said Dr. Willy Japaries MARS, alumni of the University of Indonesia.

As quoted in Biology Pharmaceutical Bulletin, the researchers said, the whole extract of Myrmecodia Sarang semut suppressed the proliferation of human tumor cells. In tests it proved the effectiveness of EC50 reaching 9.97 mg / ml in methanol extract, meaning that in just a small dose, 9.97 mg/ml, ant nest extract can suppress 50% rate of growth of cancer cells. Meanwhile, EC50 in water extract is 22.3 mg / ml; methanol-water mixture, 11.3 mg / ml. Researches then, confirmed such empirical experience of many people who recover from cancer by consuming this product.

So far it has been reported that the extract of methanol, methanol: water (1: 1), and water from ant hill has been shown to inhibit the growth of some types of cancer and tumor cells in vitro activity is quite high. One mechanism that has been revealed is the induction of apoptosis as indicated by the change in morphology and DNA fragmentation.

Ethanol extract of anthill also reported active inhibitor compound containing histone deacetylase (HDAC) which has an effective anticancer activity. HDAC inhibitors are a class of active compounds that are currently being tested clinically as anticancer. HDAC inhibitors have been shown to inhibit the growth of tumor cells, induce differentiation, and cause apoptotic cell death of cancer cells of breast, lung, ovary, prostate and colon. HDAC inhibitors allegedly cause transcriptional activation of several genes whose expression causes inhibition of tumor growth.

Water and chloroform extract of ant hill H. formicarum have also been reported to have strong antioxidant activity through the free radical test 1,1-diphenyl-2-picrylhydrazyl (DPPH) with inhibitory concentration (IC50) respectively by 32.95 mg / ml and 39 , 1 mg / ml. A pure compound which has been isolated from the hexane extract of H. formicarum is stigmasterol, has cytotoxic activity against breast cancer cells and cells of nasopharyngeal cancer with LC50 values of 87.7 and 34.3 mg / ml.

According to Prof. Dr. Sumali Wiryowidagdo, professor of the Department of Pharmacy, University of Indonesia, epiphytic plants such as Myrmecodia ant hill is indeed highly potential as a drug. Any plant living in symbiosis with other orgnisms, is usually rich in secondary metabolites. All creatures have a primary metabolite among others: carbohydrates, proteins, fats, and fatty acids. Meanwhile, secondary metabolites such as alkaloids, terpenoids, steroids and glycosides are not always present in all plants.

Other scientific research was conducted by Muhammad Ahkam Subroto to ensure the safety of consuming Myrmecodia Sarang semut extract. March 2006, he tested the safety level of consumption of the Myrmecodia Sarang semut extract. Water extracts of the plant was given to 3 groups of rat; 1 other group, the control, is not given the extract. Each group of rat consists of 10 animals, 5 male and 5 female, 3 months old, and weighs 16 grams.

After fasted for eight hours, 3 groups of rat were given the extract Myrmecodia Sarang semut with a subsequent dose of 7.5 microliters to group I, 75 microliters (II), and 750 microliters (III). Extract is administered orally. When converted to human equivalent weighing 50 kg, a dose equivalent to 7.5 microliter for rat is 30 tablespoons for human. Dose trials are typically only up to 2 g. The dose was doubled to determine the level of intoxication, said doctoral alumnus of the University Of New South Wales Sydney, Australia.

The result? Until day 5, the extract Myrmecodia Sarang semut for all doses have not affected the performance of the kidney, liver, heart, spleen, reproductive organs, and lungs. That is, the 6 organs were still functioning normally. On the 12th day, the organs’ function of rat in group I and II, registered no change when compared with the control group. However, in group III, kidney degeneration and lysis of the epithelial tubule cells are observed.

Meanwhile kidney – function in both group I and II only shows degeneration on the 19th day of experiment. On the same day, all groups show evidence of fatty liver. Only two organs are impaired; 4 other organs mentioned earlier, are still functioning properly. However, the kidney and liver damage began to recover and reverse on day 23. That means the cells are already adapting to the new environment.

The research proved that the consumption of 3 times 1 tablespoon of extract per day is still very very safe. Safety issues are also followed up by Ahkam through chronic toxicity tests. The rodents are involved once again. They were divided into 2 groups, each consisting of 5 males and 5 females. A group was given 1,500 microliters; group B, 3000 microliter of water extract of Myrmecodia ant hill.

Although the dose is increased up to 400 times, 3 weeks passed and none of the rat was dying. All the member of the Rodentia family remains healthy. The toxicity test was finally terminated. LD50 (lethal dosage or a lethal dose) was not found. So apparently with a concentration up to 400 times is still not toxic enough to kill. That is good news, although we may have to wait for another research on 1,000 times concentration. “However, such a high dose is not practical as it requires human to consume up to one kilogram of extract,” the LIPI’s principal investigator said.

Ahkam concluded that the LD50 numbers of ant hill is very high so that the safety of consumers is ensured. According to Prof. Dr. Sumali criterion, a great remedy is one with the effective dose (ED50) way apart from its LD50. “The higher the LD50 value the better it is,” said Sumali. Compared with chemotherapy for example, the lethal dose is just 10 times effective dose concentration, while the ant nest, doses are up to 400 times, and yet no demise observed.

With research findings that consumer safety was assured in Myrmecodia Sarang semut. It is therefore safe, for consumers to also partake other drugs to combat the onslaught of various diseases, at the same time. Consumers need not worry of the side effect.

Scientific research carried out by various parties was just the first step to uncover the potential of the Myrmecodia ant hill. In vitro test is not enough because, in vitro tests cannot guarantee success in vivo. Many factors such as hormones and other body’s actions may affect its mechanism of action.

We have now introduced an herbal plant Myrmecodia Sarang semut from Papua who also got tremendous response from the public. Myrmecodia Sarang semut has many benefits for the treatment of various diseases too, ranging from mild ailments such as nosebleeds, ulcers, gout and hemorrhoids to severe diseases such as tumors, cancer, tuberculosis and coronary heart disease. In addition, this plant can improve and facilitate the production of breast milk, and restore the health of women after childbirth, increase stamina, and as an aphrodisiac (increases sexual desire).

In conclusion it should be emphasized here that of the many species of ants that nest there, there are only three species of medicinal accordance with the traditional knowledge of local population in Southeast Asia, namely H. formicarum, M. and M. tuberosa pendans. Therefore, for safety’s sake it is suggested that people use to be careful in selecting the right type of ant nest for treatment.

How to use the extract?

We are the suppliers of authentic Myrmecodia Sarang semut (anthill plant) directly from trusted and registered extractor in Indonesia. The product we offer have passed strict extraction protocols, to ensure consistency and quality of the product. We provide consistent 3:1 ratio extraction by water and ethanol solvent to make sure all the plant flavonoids are thoroughly extracted.

There are 2 forms of ant hill products: dry powder and extract in capsules. Powderized product needs to be brewed for hours before consuming. The time taken to prepare the decoction, and the relatively low yield of this method makes this product form unpopular. Extracted form in capsules is the more popular form.

In general, children aged under 10 years were given to drink half the adult dose

As for preparations in capsule form (@ 500 mg) dose treatment for any disease is generally 2 capsules at a time, 3 times a day, and for general maintenance is 2 x 1 capsule daily.

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